Research Interests:

Our laboratory studies macromolecular structure with an aim toward in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and biochemical methods of analysis. The program emphasizes two broad themes; crystallographic studies on molecules of immediate interest, and methodology development. Most of the macromolecules that we have under study relate to one or more of a few broad biological areas: cellular signal transduction and metalloproteins. The same systems have been chosen as subjects for methodology development. The methodology development includes the development of various crystallographic tools that create the HKL Package.

Another research area is high-throughput crystallography and structural genomics. Our lab is involved in a number of large, biomedically oriented projects that will revolutionize biomedical research in this decade. We are a member of the Midwest Center for Structural Genomics and the New York Structural Genomics Research Consortium (both centers of the NIH Protein Structure Initiative), and the Center for Structural Genomics of Infectious Disease (a project of the NIAID). We are also a part of the Enzyme Function Initiative (an NIH Glue Grant). We develop widely used methodology that is used in thousands of structural biology laboratories around the world. We collaborate with many synchrotron beamlines, in particular, with the Structural Biology Center at the Advanced Photon Source.

Lab Members

	Jacek Bajor, Visiting Graduate Student, jacek_b@iwonka.med.virginia.edu
	Mahendra Chordia, Visiting Senior Research Scientist, mahendra@iwonka.med.virginia.edu
	Maksymilian Chruszcz, Instructor, maks@iwonka.med.virginia.edu
	David Cooper, Instructor, dcoop@iwonka.med.virginia.edu
	Marcin Cymborowski, Research Assistant, marcel@iwonka.med.virginia.edu
	Matt Demas, Lab Technician, matt_d@iwonka.med.virginia.edu
	Marcin Domagalski, Visiting Graduate Student, marcin_d@iwonka.med.virginia.edu
	Jose Font, Visiting Faculty, font@iwonka.med.virginia.edu
	Zbigniew Fratczak, Research Assistant, zbigniew_f@iwonka.med.virginia.edu
	Juliusz Gonera, Research Assistant, juliusz_g@iwonka.med.virginia.edu
	Marek Grabowski, Postdoctoral Research Associate, marek@iwonka.med.virginia.edu
	Jing Hou, Postdoctoral Research Associate, houjing@iwonka.med.virginia.edu
	Aleksandra Knapik, Visiting Graduate Student, aleksandra@iwonka.med.virginia.edu
	Elizabeth MacLean, Research Assistant, beth_m@iwonka.med.virginia.edu
	Karolina Majorek, Visiting Graduate Student, karolina_m@iwonka.med.virginia.edu
	Katarzyna Mikolajczak, Visiting Graduate Student, kasia_m@iwonka.med.virginia.edu
	Ania Milaczewska, Visiting Graduate Student, ania_m@iwonka.med.virginia.edu
	Helena Moreno Chacon, Visiting Graduate Student, helena_mc@iwonka.med.virginia.edu
	Ewa Niedzialkowska, Visiting Graduate Student, ewa_n@iwonka.med.virginia.edu
	Tomasz Osinski, Visiting Graduate Student, tomek_o@iwonka.med.virginia.edu
	Janusz Petkowski, Graduate Student, janusz@iwonka.med.virginia.edu
	Przemek Porebski, Visiting Graduate Student, przemek@iwonka.med.virginia.edu
	Ivan Shabalin, Research Associate, ivan_s@iwonka.med.virginia.edu
	Igor Shumilin, Instructor, igor@iwonka.med.virginia.edu
	Rob Solberg, Lab Technician, rob_s@iwonka.med.virginia.edu
	Karolina Tkaczuk, Postdoctoral Research Associate, karolina@iwonka.med.virginia.edu
	Rachel Vigour, Technician, rachel_v@iwonka.med.virginia.edu
	Heping Zheng, Postdoctoral Research Associate, dust@iwonka.med.virginia.edu
	Matthew Zimmerman, Instructor, matt@iwonka.med.virginia.edu

Former Lab Members

	Prof. Krzystof Lewinski, Professor, Jagellonian University, Krakow, Poland
	Prof. Hai Bin Luo, Professor, Research Center for Drug Discovery, Sun Yat-Sen University, Guangzhou, China
	Prof. Diana Tomchick, Professor, UT Southwestern Medical Center, Dallas, TX
	Dr. James Spencer, Lecturer, Bristol University, Bristol, UK
	Dr. Ekaterina Filippova, Research Associate, Northwestern University, Chicago, IL
	Dr. Olga Kirillova, Research Associate, Oregon Health and Science University, Portland, OR
	Dr. Katarzyna Koclega, Bio-Tech Consulting LTD, Warsaw, Poland
	Aleksandra Kos, Graduate Student, Swiss Institute of Bioinformatics Biozentrum, University of Basel, Switzerland
	Robert Nicholls, Graduate Student, University of York, York, UK
	Haijun Qiu, Database Administrator, The Children's Hospital of Philadelphia, Philadelphia, PA
	John Raynor, Structural Genomics Consortium, Oxford University, Oxford, UK
	Pawel Sledz, Gates Scholar, University of Cambridge, Cambridge, UK
	Shuren Wang, Technical Data Manager, OpenQ Inc., Charlottesville, VA
	Arjun Dayal, Co-founder, Monte Carlo Software LLC